Journal
ORAL DISEASES
Volume 17, Issue 5, Pages 499-507Publisher
WILEY
DOI: 10.1111/j.1601-0825.2010.01782.x
Keywords
temporomandibular joint; condyle; in vivo micro-computed tomography; complete Freund's adjuvant; inflammation
Categories
Funding
- Japan Society for the Promotion of Science [17390504, 17390555, 17591952, 18390551, 18592069]
- Ministry of Education, Culture, Sports, Science, and Technology at Nihon University
- Nihon University
- Nihon University School of Dentistry
- Grants-in-Aid for Scientific Research [18390551, 17390555, 17591952, 18592069, 17390504] Funding Source: KAKEN
Ask authors/readers for more resources
Objective: Injection of complete Freund's adjuvant (CFA) into the temporomandibular joint (TMJ) causes acute swelling around the joint and subsequent morphological alterations in the condyle. We aimed to evaluate changes in the three-dimensional architecture of the condyle induced with CFA. Materials and methods: The CFA was injected into the unilateral TMJ of rats and morphological changes in the condyle were assessed repeatedly for 14 days by in vivo micro-CT. Results: Osseous abnormalities of condyle were first observed at 3-5 days after CFA injection on the tomographic images, and the condylar deformation became more obvious thereafter. Among 12 condyles examined at 14 days postinjection, osteophytosis was observed in all of the specimens and bone erosion coexisted in five condyles. None of the saline-treated condyles showed architectural changes. Significant changes were detected in the mesiolateral and rostrocaudal widths of the CFA-treated condyles at 10-14 days postinjection (P < 0.01). The extent of both condylar bone formation and resorption was greater in the CFA-injected TMJs than in saline-injected TMJs (P < 0.05). Conclusion: These results indicate that CFA causes dynamic morphological changes in the condyle and that our experimental approach will provide new insights into the subacute inflammatory processes in the TMJ.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available