Journal
ORAL DISEASES
Volume 16, Issue 4, Pages 328-332Publisher
WILEY-BLACKWELL PUBLISHING, INC
DOI: 10.1111/j.1601-0825.2009.01632.x
Keywords
proliferative verrucous leukoplakia; oral
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Proliferative verrucous leukoplakia (PVL) is of uncertain etiology but may be associated with human papillomavirus (HPV) infection. Proliferative verrucous leukoplakia is seen mainly in older women, beginning as a simple slow-growing, persistent leukoplakia that tends to spread and become multifocal and affect the gingival frequently. In time, PVL develops exophytic, wart-like or erythroplakic areas that become squamous carcinomas. Proliferative verrucous leukoplakia appears to resist to all attempts at therapy and often recurs.
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