Journal
ORAL DISEASES
Volume 14, Issue 7, Pages 582-590Publisher
WILEY
DOI: 10.1111/j.1601-0825.2007.01424.x
Keywords
Candida; biofilm; antifungal resistance
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Funding
- Research Grants Council of Hong Kong CERG [HKU 7624/06M]
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Candida is the major fungal pathogen of humans causing a variety of afflictions ranging from superficial mucosal diseases to deep seated mycoses. Biofilm formation is a major virulence factor in the pathogenicity of Candida, and Candida biofilms are difficult to eradicate especially because of their very high antifungal resistance. Consequently, research into the pathogenicity of Candida has focused on the prevention and management of biofilm development, their architecture, and antifungal resistance. Although studies have shed some light, molecular mechanisms that govern biofilm formation and pathogenicity still await full clarification. This review outlines the key features of what is currently known of Candida biofilm development, regulation and antifungal resistance and, their proteomics.
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