Journal
OPTOMETRY AND VISION SCIENCE
Volume 88, Issue 1, Pages 36-38Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/OPX.0b013e3182058ead
Keywords
glaucoma; pharmacology; history
Categories
Funding
- Research to Prevent Blindness, Inc.
- Alcon Laboratories
- Aqueous Biomedical
- Pfizer, Inc.
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The history of glaucoma pharmacology begins in 1862 with the isolation of physostigmine from the calabar bean. The discovery of epinephrine's intraocular pressure lowering capacity came along some 40 years later. During the 20th century, drug discovery and development accelerated, with the introduction of carbonic anhydrase inhibitors, beta blockers, and prostaglandin analogs. This survey of the history of glaucoma medications reviews some of the pivotal stories behind the development of the drugs that we use daily to manage our patients with glaucoma. In addition, some unmet needs that persist in glaucoma pharmacology are discussed. (Optom Vis Sci 2011; 88: 36-38)
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