Journal
OPTICS LETTERS
Volume 39, Issue 9, Pages 2599-2602Publisher
Optica Publishing Group
DOI: 10.1364/OL.39.002599
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Funding
- NIH [RO1EB016034, R01CA170734, T32CA138312]
- NSF [0645080]
- Life Sciences Discovery Fund [3292512]
- Department of Bioengineering at University of Washington
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [1236309] Funding Source: National Science Foundation
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Optically activated cavitation in a nanoemulsion contrast agent is proposed for therapeutic applications. With a 56 degrees C boiling point perfluorohexane core and highly absorptive gold nanospheres at the oil-water interface, cavitation nuclei in the core can be efficiently induced with a laser fluence below medical safety limits (70 mJ/cm(2) at 1064 nm). This agent is also sensitive to ultrasound (US) exposure and can induce inertial cavitation at a pressure within the medical diagnostic range. Images from a high-speed camera demonstrate bubble formation in these nanoemulsions. The potential of using this contrast agent for blood clot disruption is demonstrated in an in vitro study. The possibility of simultaneous laser and US excitation to reduce the cavitation threshold for therapeutic applications is also discussed. (C) 2014 Optical Society of America
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