4.6 Article

Dual spectrometer system with spectral compounding for 1-μm optical coherence tomography in vivo

Journal

OPTICS LETTERS
Volume 39, Issue 23, Pages 6727-6730

Publisher

OPTICAL SOC AMER
DOI: 10.1364/OL.39.006727

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Funding

  1. Nanyang Technological University
  2. National Research Foundation Singapore [NRF2013NRF-POC001-021]
  3. National Medical Research Council Singapore [NMRC/CBRG/0036/2013]
  4. Ministry of Education Singapore [MOE2013-T2-2-107]
  5. Nanyang President Graduate Scholarship

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1 mu m axial resolution spectral domain optical coherence tomography (OCT) is demonstrated for in vivo cellular resolution imaging. Output of two superluminescent diode sources is combined to provide near infrared illumination from 755 to 1105 nm. The spectral interference is detected using two spectrometers based on a Si camera and an InGaAs camera, respectively. Spectra from the two spectrometers are combined to achieve an axial resolution of 1.27 mu m in air. Imaging was conducted on zebra fish larvae to visualize cellular details. (C) 2014 Optical Society of America

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