Journal
OPTICS LETTERS
Volume 39, Issue 19, Pages 5594-5597Publisher
OPTICAL SOC AMER
DOI: 10.1364/OL.39.005594
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Funding
- National Science Foundation [CBET-1039562]
- National Institutes of Health [1R21EY023451]
- Research School+
- European Space Agency
- RWTUV Stiftung
- Research to Prevent Blindness
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Spectroscopic analysis of biological tissues can provide insight into changes in structure and function due to disease or injury. Depth-resolved spectroscopic measurements can be implemented for tissue imaging using optical coherence tomography (OCT). Here, spectroscopic OCT is applied to in vivo measurement of burn injury in a mouse model. Data processing and analysis methods are compared for their accuracy. Overall accuracy in classifying burned tissue was found to be as high as 91%, producing an area under the curve of a receiver operating characteristic curve of 0.97. The origins of the spectral changes are identified by correlation with histopathology. (C) 2014 Optical Society of America
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