Journal
OPTICS LETTERS
Volume 38, Issue 15, Pages 2800-2803Publisher
OPTICAL SOC AMER
DOI: 10.1364/OL.38.002800
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Funding
- National Institutes of Health [DP1 EB016986, R01 EB008085, R01 CA134539, U54 CA136398, R01 CA157277, R01 CA159959]
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Photoacoustic tomography (PAT) is a hybrid imaging technique that has broad preclinical and clinical applications. Based on the photoacoustic effect, PAT directly measures specific optical absorption, which is the product of the tissue-intrinsic optical absorption coefficient and the local optical fluence. Therefore, quantitative PAT, such as absolute oxygen saturation (sO(2)) quantification, requires knowledge of the local optical fluence, which can only be estimated through invasive measurements or sophisticated modeling of light transportation. In this Letter, we circumvent this requirement by taking advantage of the dynamics in sO(2). The new method works when the sO(2) transition can be simultaneously monitored with multiple wavelengths. For each wavelength, the ratio of photoacoustic amplitudes measured at different sO(2) states is utilized. Using the ratio cancels the contribution from optical fluence and allows calibration-free quantification of absolute sO(2). The new method was validated through both phantom and in vivo experiments. (C) 2013 Optical Society of America
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