Journal
OPTICS LETTERS
Volume 38, Issue 6, Pages 992-994Publisher
OPTICAL SOC AMER
DOI: 10.1364/OL.38.000992
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Funding
- SU2P pilot project
- EPSRC [EP/D078555/1, EP/F05999X/1]
- Engineering and Physical Sciences Research Council [EP/G042446/1, EP/F05999X/1, EP/D078555/1] Funding Source: researchfish
- Medical Research Council [MR/J004448/1] Funding Source: researchfish
- EPSRC [EP/F05999X/1, EP/G042446/1, EP/D078555/1] Funding Source: UKRI
- MRC [MR/J004448/1] Funding Source: UKRI
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Within optogenetics there is a need for compact light sources that are capable of delivering light with excellent spatial, temporal, and spectral resolution to deep brain structures. Here, we demonstrate a custom GaN-based LED probe for such applications and the electrical, optical, and thermal properties are analyzed. The output power density and emission spectrum were found to be suitable for stimulating channelrhodopsin-2, one of the most common light-sensitive proteins currently used in optogenetics. The LED device produced high light intensities, far in excess of those required to stimulate the light-sensitive proteins within the neurons. Thermal performance was also investigated, illustrating that a broad range of operating regimes in pulsed mode are accessible while keeping a minimum increase in temperature for the brain (0.5 degrees C). This type of custom device represents a significant step forward for the optogenetics community, allowing multiple bright excitation sites along the length of a minimally invasive neural probe. (C) 2013 Optical Society of America
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