Journal
OPTICS LETTERS
Volume 38, Issue 24, Pages 5228-5231Publisher
OPTICAL SOC AMER
DOI: 10.1364/OL.38.005228
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Funding
- NIH [DP1 EB016986, R01 EB008085, R01 CA134539, U54 CA136398, R01 CA157277, R01 CA159959]
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Photoacoustic thermography is a promising tool for temperature measurement in deep tissue. Here we propose an absolute temperature measurement method based on the dual temperature dependences of the Gruneisen parameter and the speed of sound in tissue. By taking ratiometric measurements at two adjacent temperatures, we can eliminate the factors that are temperature irrelevant but difficult to correct for in deep tissue. To validate our method, absolute temperatures of blood-filled tubes embedded similar to 9 mm deep in chicken tissue were measured in a biologically relevant range from 28 degrees C to 46 degrees C. The temperature measurement accuracy was similar to 0.6 degrees C. The results suggest that our method can be potentially used for absolute temperature monitoring in deep tissue during thermotherapy. (C) 2013 Optical Society of America
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