Journal
OPTICS LETTERS
Volume 37, Issue 11, Pages 2001-2003Publisher
OPTICAL SOC AMER
DOI: 10.1364/OL.37.002001
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Funding
- Howard Hughes Medical Institute
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The intrinsic aberrations of high-NA gradient refractive index (GRIN) lenses limit their image quality as well as field of view. Here we used a pupil-segmentation-based adaptive optical approach to correct the inherent aberrations in a two-photon fluorescence endoscope utilizing a 0.8 NA GRIN lens. By correcting the field-dependent aberrations, we recovered diffraction-limited performance across a large imaging field. The consequent improvements in imaging signal and resolution allowed us to detect fine structures that were otherwise invisible inside mouse brain slices. (C) 2012 Optical Society of America
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