Journal
OPTICS LETTERS
Volume 36, Issue 7, Pages 1134-1136Publisher
OPTICAL SOC AMER
DOI: 10.1364/OL.36.001134
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Funding
- National Institutes of Health (NIH) [R01 EB000712, R01 EB008085, R01 CA134539, U54 CA136398, 5P60 DK02057933]
- Microphotoacoustics, Inc.
- Endra, Inc.
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We developed second-generation (G2) optical-resolution photoacoustic microscopy (OR-PAM). Incorporation of a novel acoustic detection scheme improved upon the sensitivity of our first-generation (G1) system by 18.4 dB, deepening the in vivo tissue penetration to 1.2mm at 570nm. Moreover, translating the imaging head instead of the living object accelerated the scanning speed by a factor of 5, widening the field of view within the same acquisition time. Mouse ears, as well as mouse brains with intact craniums, were imaged in vivo in both total concentration and oxygen saturation of hemoglobin. (C) 2011 Optical Society of America
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