Journal
OPTICS LETTERS
Volume 36, Issue 20, Pages 4107-4109Publisher
OPTICAL SOC AMER
DOI: 10.1364/OL.36.004107
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Funding
- Natural Sciences and Engineering Research Council (NSERC) [355544-2008, 375 340-2009, STPGP 396 444]
- Terry- Fox Foundation
- Canadian Cancer Society [TFF 019 237, TFF 019 240, CCS 2011-700718]
- Alberta Cancer Research Institute [ACB 23 728]
- Canada Foundation for Innovation
- Leaders Opportunity Fund [18472]
- Alberta Advanced Education & Technology, Small Equipment Grants Program [URSI09007SEG]
- Microsystems Technology Research Initiative [MSTRI RES0003166]
- University of Alberta
- Alberta Ingenuity/Alberta Innovates scholarships for graduate and undergraduate students
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In this Letter, the capability of label-free fiber-based optical-resolution photoacoustic microscopy is demonstrated. This real-time imaging system takes advantage of image-guide fibers and a unique fiber laser. The 800 mu m image-guide consists of 30,000 individual single-mode fibers in a bundle and the diode-pumped, pulsed Ytterbium fiber laser is utilized to perform up to 600 kHz repetition rate. Phantom studies indicate 7 mu m resolution. The proposed setup keeps many of the powerful properties of previous tabletop OR-PAM systems, but also offers a submillimeter probe footprint and high flexibility due to the nature of the image-guide. This system could have significant clinical impact for endoscopic applications where the thin fiber can be inserted into the body. (C) 2011 Optical Society of America
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