Journal
OPTICS LETTERS
Volume 35, Issue 22, Pages 3751-3753Publisher
OPTICAL SOC AMER
DOI: 10.1364/OL.35.003751
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Funding
- National Institutes of Health (NIH) [CA 143663, EB 008101, CA 141203]
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [0968038] Funding Source: National Science Foundation
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Plasmonic metal nanoparticles are used in photoacoustic imaging as contrast agents because of their resonant optical absorption properties in the visible and near-IR regions. However, the nanoparticles could accumulate and result in long-term toxicity in vivo, because they are generally not biodegradable. Recently, biodegradable plasmonic gold nanoclusters, consisting of sub-5 nm primary gold nanoparticles and biodegradable polymer stabilizer, were introduced. In this Letter, we demonstrate the feasibility of biodegradable nanoclusters as a photoacoustic contrast agent. We performed photoacoustic and ultrasound imaging of a tissue-mimicking phantom with inclusions containing nanoclusters at various concentrations. The results indicate that the biodegradable gold nanoclusters can be used as effective contrast agents in photoacoustic imaging. (C) 2010 Optical Society of America
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