Journal
OPTICS LETTERS
Volume 35, Issue 9, Pages 1482-1484Publisher
OPTICAL SOC AMER
DOI: 10.1364/OL.35.001482
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Funding
- NIH [R01 EB000712, EB000712A2S1, R01 EB00071207S2, R01 EB008085, R01 CA113453901, U54 CA136398, 5P60 DK02057933]
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We developed section-illumination photoacoustic microscopy capable of dynamic in vivo imaging of microvessels as small as 30 mu m in diameter. The section illumination improved the elevational resolution while an ultrasound array provided the in-plane axial and lateral resolutions. Using the imaging system, we monitored the wash-in dynamics of Evans Blue in the microcirculation of mouse ears at 249 Hz 2D and 0.5 Hz 3D image acquisition rates. Such observation allowed us to differentiate the arterioles from the venules. In the future, the technology may be used to study angiogenesis, diabetes-induced vascular complications, and pharmacokinetics. (C) 2010 Optical Society of America
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