Journal
OPTICS LETTERS
Volume 34, Issue 17, Pages 2566-2568Publisher
OPTICAL SOC AMER
DOI: 10.1364/OL.34.002566
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Funding
- National Institutes of Health (NIH) [1-RO1-EB006432]
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB006432] Funding Source: NIH RePORTER
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We report on a systematic study of upconverting fluorescence signal generation within turbid phantoms and real tissues. An accurate three-point Green's function, describing the forward model of photon propagation, is established and experimentally validated. We further demonstrate, for the first time to our knowledge, autofluorescence-free transillumination imaging of mice that have received biocompatible upconverting nanoparticles. The method holds great promise for artifact-free whole-body visualization of optical molecular probes. (C) 2009 Optical Society of America
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