Journal
OPTICS LETTERS
Volume 34, Issue 19, Pages 2961-2963Publisher
OPTICAL SOC AMER
DOI: 10.1364/OL.34.002961
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Funding
- National Institutes of Health (NIH) [7R21EB008800-02]
- University of Wisconsin-Milwaukee
- The Lynde and Harry Bradley Foundation
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We have developed a multimodal imaging technique by integrating photoacoustic microscopy and spectral-domain optical coherence tomography to provide simultaneous volumetric microscopic imaging of both optical absorption and scattering contrasts in biological tissues. In the integrated system, the two imaging modalities share the same optical scanning and delivery mechanisms after their probing and illumination light beams are combined. By further synchronizing the image acquisitions, the images from the two modalities are intrinsically registered. The capabilities of this novel technique were demonstrated by imaging both the microanatomy and microvasculature in mouse ears in vivo. (C) 2009 Optical Society of America
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