Journal
OPTICS LETTERS
Volume 33, Issue 16, Pages 1783-1785Publisher
OPTICAL SOC AMER
DOI: 10.1364/OL.33.001783
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- National Institutes of Health (NIH) [R01CA100559-01A1]
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Calibration of the diffuse reflectance spectrum for instrument response and time-dependent fluctuation as well as interdevice variations is complicated, time consuming, and potentially inaccurate. We describe a novel fiber optic probe with a real-time self-calibration capability that can be used for tissue optical spectroscopy. The probe was tested in a number of liquid phantoms over a relevant range of tissue optical properties. Absorption and scattering coefficients are extracted with an average absolute error and standard deviation of 6.9%+/- 7.2% and 3.5%+/- 1.5%, respectively. (C) 2008 Optical Society of America.
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