Journal
OPTICS EXPRESS
Volume 22, Issue 13, Pages 16606-16618Publisher
OPTICAL SOC AMER
DOI: 10.1364/OE.22.016606
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Funding
- National Institutes of Health (NIBIB) [R01 EB012479]
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There is an inherent trade-off between transverse resolution and depth of field (DOF) in optical coherence tomography (OCT) which becomes a limiting factor for certain applications. Multifocal OCT and interferometric synthetic aperture microscopy (ISAM) each provide a distinct solution to the trade-off through modification to the experiment or via post-processing, respectively. In this paper, we have solved the inverse problem of multifocal OCT and present a general algorithm for combining multiple ISAM datasets. Multifocal ISAM (MISAM) uses a regularized combination of the resampled datasets to bring advantages of both multifocal OCT and ISAM to achieve optimal transverse resolution, extended effective DOF and improved signal-to-noise ratio. We present theory, simulation and experimental results. (C) 2014 Optical Society of America
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