Journal
OPTICS EXPRESS
Volume 21, Issue 16, Pages 19219-19227Publisher
OPTICAL SOC AMER
DOI: 10.1364/OE.21.019219
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Funding
- Lehigh University Start-up Fund
- National Institute of Health / National Institute of Biomedical Imaging and Bioengineering (NIH/NIBIB) Pathway to Independence Award [R00-EB010071]
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High speed, high resolution and high sensitivity are desirable for optical coherence tomography (OCT). Here, we demonstrate a space-division multiplexing (SDM) technology that translates long coherence length of a commercially available wavelength tunable laser into high OCT imaging speed. We achieved an effective 800,000 A-scans/s imaging speed using a 100,000 Hz tunable vertical cavity surface-emitting laser (VCSEL). A sensitivity of 94.6 dB and a roll-off of < 2 dB over similar to 30 mm imaging depth were measured from a single channel in the prototype SDM-OCT system. An axial resolution of similar to 11 mu m in air (or similar to 8.3 mu m in tissue) was achieved throughout the entire depth range. An in vivo, 3D SDM-OCT volume of an entire Drosophila larva consisting of 400 x 605 A-scans was acquired in 0.37 seconds. Synchronized cross-sectional OCT imaging of three different segments of a beating Drosophila larva heart is demonstrated. The SDM technology provides a new orthogonal dimension for further speed improvement for OCT with favorable cost scaling. SDM-OCT also preserves image resolution and allows synchronized cross-sectional and three-dimensional (3D) imaging of biological samples, enabling new biomedical applications. (c) 2013 Optical Society of America
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