Journal
OPTICS EXPRESS
Volume 20, Issue 11, Pages 11582-11597Publisher
OPTICAL SOC AMER
DOI: 10.1364/OE.20.011582
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Funding
- Agentschap NL Innovation-Oriented Research Programme (IOP) Photonic Devices under the HYMPACT Project [IPD083374]
- MIRA Institute for Biomedical Technology and Technical Medicine
- VICI of Netherlands Technology Foundation STW [10831]
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We acquired images of breast malignancies using the Twente photoacoustic mammoscope (PAM), to obtain more information about the clinical feasibility and limitations of photoacoustic mammography. Results were compared with conventional imaging and histopathology. Ten technically acceptable measurements on patients with malignancies and two measurements on patients with cysts were performed. In the reconstructed volumes of all ten malignant lesions, a confined region with high contrast with respect to the background could be seen. In all malignant cases, the PA contrast of the abnormality was higher than the contrast on x-ray mammography. The PA contrast appeared to be independent of the mammographically estimated breast density and was absent in the case of cysts. Technological improvements to the instrument and further studies on less suspicious lesions are planned to further investigate the potential of PAM. (C) 2012 Optical Society of America
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