Journal
OPTICS EXPRESS
Volume 19, Issue 7, Pages 6623-6634Publisher
OPTICAL SOC AMER
DOI: 10.1364/OE.19.006623
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Funding
- UWA
- National Institutes of Health [1 RC1 CA147096]
- National Science Foundation [CBET 08-52658 ARRA]
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [0852658] Funding Source: National Science Foundation
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We present the first three-dimensional (3D) data sets recorded using optical coherence elastography (OCE). Uni-axial strain rate was measured on human skin in vivo using a spectral-domain optical coherence tomography (OCT) system providing >450 times higher line rate than previously reported for in vivo OCE imaging. Mechanical excitation was applied at a frequency of 125 Hz using a ring actuator sample arm with, for the first time in OCE measurements, a controlled static preload. We performed 3D-OCE, processed in 2D and displayed in 3D, on normal and hydrated skin and observed a more elastic response of the stratum corneum in the hydrated case. (C) 2011 Optical Society of America
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