Journal
OPTICS EXPRESS
Volume 18, Issue 22, Pages 23153-23160Publisher
OPTICAL SOC AMER
DOI: 10.1364/OE.18.023153
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Funding
- NSF [CBET 0853500, ECCS 0901154]
- UC Discovery/Abraxis Bioscience Biotechnology Award [178517]
- NIH Roadmap for Medical Research Nanomedicine Initiative [PN2EY018228]
- Broad Center of Regenerative Medicine and Stem Cell Research at UCLA
- Prostate Cancer Foundation
- Directorate For Engineering [0901154, 0853500] Funding Source: National Science Foundation
- Div Of Chem, Bioeng, Env, & Transp Sys [0853500] Funding Source: National Science Foundation
- Div Of Electrical, Commun & Cyber Sys [0901154] Funding Source: National Science Foundation
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We report a photothermal nanoblade that utilizes a metallic nanostructure to harvest short laser pulse energy and convert it into a highly localized and specifically shaped explosive vapor bubble. Rapid bubble expansion and collapse punctures a lightly-contacting cell membrane via high-speed fluidic flows and induced transient shear stress. The membrane cutting pattern is controlled by the metallic nanostructure configuration, laser pulse polarization, and energy. Highly controllable, sub-micron sized circular hole pairs to half moon-like, or cat-door shaped, membrane cuts were realized in glutaraldehyde treated HeLa cells. (C) 2010 Optical Society of America
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