Journal
OPTICS EXPRESS
Volume 18, Issue 9, Pages 8867-8877Publisher
OPTICAL SOC AMER
DOI: 10.1364/OE.18.008867
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Funding
- National Institutes of Health [CA149740, CA141203, EB008101, CA135315]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [0821312] Funding Source: National Science Foundation
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Photothermal stability and, therefore, consistency of both optical absorption and photoacoustic response of the plasmonic nanoabsorbers is critical for successful photoacoustic image-guided photothermal therapy. In this study, silica-coated gold nanorods were developed as a multifunctional molecular imaging and therapeutic agent suitable for image-guided photothermal therapy. The optical properties and photothermal stability of silica-coated gold nanorods under intense irradiation with nanosecond laser pulses were investigated by UV-Vis spectroscopy and transmission electron microscopy. Silica-coated gold nanorods showed increased photothermal stability and retained their superior optical properties under much higher fluences. The changes in photoacoustic response of PEGylated and silica-coated nanorods under laser pulses of various fluences were compared. The silica-coated gold nanorods provide a stable photoacoustic signal, which implies better imaging capabilities and make silica-coated gold nanorods a promising imaging and therapeutic nano-agent for photoacoustic imaging and image-guided photothermal therapy. (C) 2010 Optical Society of America
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