Journal
OPTICS EXPRESS
Volume 18, Issue 2, Pages 1278-1282Publisher
OPTICAL SOC AMER
DOI: 10.1364/OE.18.001278
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Funding
- UWM start-up fund
- UWM Research Growth Initiative
- Shaw Scientist Award
- Juvenile Diabetes Research Foundation [5-2009-498]
- National Institutes of Health [7R21EB008800-02]
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Since the photoacoustic effect relies only on the absorbed optical energy, the back-reflected photons from samples in optical-resolution photoacoustic microscopy are usually discarded. By employing a 2 x 2 single-mode fiber optical coupler in a laser-scanning optical-resolution photoacoustic microscope for delivering the illuminating laser light and collecting the back reflected photons, a fiber-optic confocal microscope is integrated with the photoacoustic microscope. Thus, simultaneous multimodal imaging can be achieved with a single light source and images from the two modalities are intrinsically registered. Such capabilities are demonstrated in imaging both phantoms and small animals in vivo. (C) 2010 Optical Society of America
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