Journal
OPTICS EXPRESS
Volume 18, Issue 18, Pages 19120-19128Publisher
OPTICAL SOC AMER
DOI: 10.1364/OE.18.019120
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Funding
- German Federal Ministry for Education and Research BMBF [03X5514]
- Karlsruhe School of Optics & Photonics (KSOP)
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There is a strong need for low-cost biosensors to enable rapid, on-site analysis of biological, biomedical, or chemical substances. We propose a platform for label-free optical biosensors based on applying the analyte onto a surface-functionalized photonic crystal slab and performing a transmission measurement with two crossed polarization filters. This dark-field approach allows for efficient background suppression as only the photonic crystal guided-mode resonances interacting with the functionalized surface experience significant polarization rotation. We present a compact biosensor demonstrator using a low-cost light emitting diode and a simple photodiode capable of detecting the binding kinetics of a 2.5 nM solution of the protein streptavidin on a biotin-functionalized photonic crystal surface. (c) 2010 Optical Society of America
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