Journal
OPTICS EXPRESS
Volume 17, Issue 19, Pages 16450-16455Publisher
OPTICAL SOC AMER
DOI: 10.1364/OE.17.016450
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Funding
- National Institutes of Health [R01 CA092415, R01 NS46214, R01 EB000712, R01 EB008085, U54 CA136398]
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Photoacoustic microscopy is predominantly sensitive to optical absorption, while optical coherence tomography relies on optical backscattering. Integrating their complementary contrasts can provide comprehensive information about biological tissue. We have developed a dual-modality microscope that combines the two for studying microcirculation. Three-dimensional imaging of microvasculature and its local environment has been demonstrated at micrometer-order resolution using endogenous contrast in vivo. (C) 2009 Optical Society of America
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