Journal
OPTICS EXPRESS
Volume 17, Issue 5, Pages 3469-3475Publisher
OPTICAL SOC AMER
DOI: 10.1364/OE.17.003469
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Funding
- Korea Science and Engineering Foundation [M10755020002-07N5502-00210, R01-2007-000-11933-0]
- Korea Research Foundation [KRF-2006-312-CC00175]
- National Research Foundation of Korea [R01-2007-000-11933-0, 2007-04049, 2007-0054519, 2007-2004045, 과C6A1905] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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This paper demonstrates the principle of the nanoparticle-contrast-agent-enabled terahertz imaging (CATHI) technique, which yields a dramatic sensitivity of the differential signal from cancer cells with nanoparticles. The terahertz (THz) reflection signal increased beam by 20% in the cancer cells with nanoparticles of gold nano-rods (GNRs) upon their irradiation with a infrared (IR) laser, due to the temperature rise of water in cancer cells by surface plasma ploritons. In the differential mode, the THz signal from the cancer cells with GNRs was 30 times higher than that from the cancer cells without GNRs. As the high sensitivity is achieved by the surface plasmon resonance through IR laser irradiation, the resolution of the CATHI technique can be as good as a few microns and THz endoscopy becomes more feasible. (c) 2009 Optical Society of America
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