Journal
OPTICS EXPRESS
Volume 17, Issue 24, Pages 22041-22046Publisher
OPTICAL SOC AMER
DOI: 10.1364/OE.17.022041
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Funding
- Canadian Cancer Society [019237, 019249]
- Natural Sciences & Engineering Research Council of Canada (NSERC) [355544-08]
- Canada Foundation for Innovation
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We report on the development of an imaging system capable of combined ultrasound and photoacoustic imaging based on a fast-scanning single-element 25-MHz ultrasound transducer and a unique light-delivery system. The system is capable of 20 ultrasound frames per second and slower photoacoustic frame rates limited by laser pulse-repetition rates. Laser and ultrasound pulses are interlaced for co-registration of photoacoustic and ultrasound images. In vivo imaging of a human finger permits ultrasonic visualization of vessel structures and speckle changes indicative of blood flow, while overlaid photoacoustic images highlight some small vessels that are not clear from the ultrasound scan. Photoacoustic images provide optical absorption contrast co-registered in the structural and blood-flow context of ultrasound with high-spatial resolution and may prove important for clinical diagnostics and basic science of the microvasculature. (C) 2009 Optical Society of America
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