Journal
OPTICS EXPRESS
Volume 16, Issue 23, Pages 18605-18615Publisher
OPTICAL SOC AMER
DOI: 10.1364/OE.16.018605
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Funding
- National Science Council
- National Health Research Institutes
- NTU Center for Genomic Medicine
- NTU Nano Center for Science and Technology
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The use of gold nanorods for photoacoustic molecular imaging with simultaneous multiple targeting is reported. Multiple targeting is done by utilizing the tunable optical absorption property of gold nanorods. This technique allows multiple molecular signatures to be obtained by simply switching laser wavelength. HER2 and EGFR were chosen as the primary target molecules for examining two cancer cells, OECM1 and Cal27. Both in vitro and in vivo mouse model imaging experiments were performed, with contrast enhancement of up to 10dB and 3.5dB, respectively. The potential in improving cancer diagnosis is demonstrated. (c) 2008 Optical Society of America
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