Journal
OPTICS EXPRESS
Volume 16, Issue 26, Pages 22083-22089Publisher
OPTICAL SOC AMER
DOI: 10.1364/OE.16.022083
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- The Ministry of Health, Labour and Welfare of Japan [18070501]
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We demonstrate a highly sensitive imaging method combined a terahertz time-domain spectroscopy and an interference effect for label-free protein detection on a polyvinylidene difluoride membrane. The method is based on terahertz time-domain spectroscopy and uses an interference effect. Biotin is linked to the membrane using poly ethylene glycol or poly ethylene glycol methyl ether to prevent it from being washed off. Binding of the biotin with streptavidin is then observed by measuring the terahertz signal change due to the variation of the membrane refractive index. We demonstrate the detection of the binding streptavidin protein in gradually decreasing concentrations, down to 27 ng mm(-2), using the image recorded at 1.5 THz. (C) 2008 Optical Society of America
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