Journal
OPTICS EXPRESS
Volume 17, Issue 1, Pages 80-86Publisher
OPTICAL SOC AMER
DOI: 10.1364/OE.17.000080
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Funding
- AFOSR, NIH [HG01506]
- NSF Nanobiology Technology Center [BSCECS9876771]
- NSF NIRT [CBET-0506966]
- National Science Foundation [ECS-9731293]
- Direct For Mathematical & Physical Scien
- Division Of Physics [0750323] Funding Source: National Science Foundation
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We present a novel process for the production of three-layer Composite Nanoparticles (CNPs) in the size range 100-300 nm with an up-converting phosphor interior, a coating of porphyrin photosensitizer, and a biocompatible PEG outer layer to prevent clearance by the reticuloendothelial system. We show that these CNPs produce millimolar amounts of singlet oxygen at NIR intensities far less than other two-photon techniques. (C) 2008 Optical Society of America
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