Journal
OPTICS EXPRESS
Volume 16, Issue 23, Pages 18764-18769Publisher
OPTICAL SOC AMER
DOI: 10.1364/OE.16.018764
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Funding
- Life Science Institute [R-397-000-615-712]
- Faculty of Engineering [R-397-000-024-112]
- National University of Singapore
- Singapore Bioimaging Consortium/ Singapore Stem Cell Consortium
- A*STAR [SBIC-SSCC RP C003/2007]
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We report a novel light microscopy method for high resolution molecular imaging of thick biological tissues with one photon excited fluorescence. Effective optical sectioning and diffraction limited spatial resolution are achieved when imaging deep inside a multiple-scattering medium by the use of focal modulation, a technique for suppressing the background fluorescence signal excited by scattered light. Our method has been validated with animal tissue and an imaging depth around 600 microns has been demonstrated. (c) 2008 Optical Society of America
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