Journal
OPTICS EXPRESS
Volume 16, Issue 12, Pages 8594-8603Publisher
OPTICAL SOC AMER
DOI: 10.1364/OE.16.008594
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Funding
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [0852417] Funding Source: National Science Foundation
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Micromechanical properties of biological cells are crucial for cells functions. Despite extensive study by a variety of approaches, an understanding of the subject remains elusive. We conducted a comparative study of the micromechanical properties of cultured alveolar epithelial cells with an oscillatory optical tweezer-based cytorheometer. In this study, the frequency-dependent viscoelasticity of these cells was measured by optical trapping and forced oscillation of either a submicron endogenous intracellular organelle (intra-cellular) or a 1.5 mu m silica bead attached to the cytoskeleton through trans-membrane integrin receptors (extra-cellular). Both the storage modulus and the magnitude of the complex shear modulus followed weak power-law dependence with frequency. These data are comparable to data obtained by other measurement techniques. The exponents of power-law dependence of the data from the intra- and extracellular measurements are similar; however, the differences in the magnitudes of the moduli from the two measurements are statistically significant. (c) 2008 Optical Society of America.
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