Journal
OPTICS EXPRESS
Volume 16, Issue 17, Pages 12737-12745Publisher
OPTICAL SOC AMER
DOI: 10.1364/OE.16.012737
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Funding
- NIH National Center for Research Resources [P41-RR02594]
- Bayer Health Care, LLC
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We demonstrate the effectiveness of intrinsic Raman spectroscopy (IRS) at reducing errors caused by absorption and scattering. Physical tissue models, solutions of varying absorption and scattering coefficients with known concentrations of Raman scatterers, are studied. We show significant improvement in prediction error by implementing IRS to predict concentrations of Raman scatterers using both ordinary least squares regression (OLS) and partial least squares regression (PLS). In particular, we show that IRS provides a robust calibration model that does not increase in error when applied to samples with optical properties outside the range of calibration. (C) 2008 Optical Society of America.
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