Journal
OPTICS COMMUNICATIONS
Volume 281, Issue 7, Pages 1771-1780Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.optcom.2007.07.069
Keywords
CdSe/ZnS quantum dots; FCS
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Funding
- NIDDK NIH HHS [R21 DK077051-01, R21 DK077051] Funding Source: Medline
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The colloidal stabilities and emission properties of CdSe/ZnS quantum dot (QD) optical probes capped with a variety of thin, hydrophilic surface coatings were studied using confocal fluorescence correlation spectroscopy. These coatings are based on mercaptoethanol, mercaptopropionic acid (with and without conjugated aminoethoxyethanol), lipopolymers (DSPE-PEG2000), cysteine (Cys), and a variety of Xaa-Cys dipeptides. The study shows that QDs with thin hydrophilic coatings can be designed that combine good colloidal stability and excellent emission properties (brightness). Furthermore, there is a general correlation between colloidal stability and brightness. The experiments reported illustrate that QDs with multiple types of thin coatings can be created for optical imaging applications in a biological environment while also maintaining a size below 10 nm. (C) 2007 Elsevier B.V. All rights reserved.
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