Journal
OPTICS AND LASERS IN ENGINEERING
Volume 49, Issue 3, Pages 361-365Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.optlaseng.2010.11.003
Keywords
Non-destructive testing; Optical coherence tomography; Terahertz pulsed imaging; Tablet coating thickness
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Funding
- UK Technology Strategy Board [AB293H]
- Fuzhou University
- Scientific Research Foundation for the Returned Overseas Chinese Scholars
- State Education Ministry, P.R. China
- National Natural Science Foundation of China [51005077]
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Optical coherence tomography (OCT) and terahertz pulsed imaging (TPI) are two powerful techniques allowing high quality cross-sectional images from within scattering media to be obtained non-destructively. In this paper, we report experimental results of using OCT and TPI for quantitatively characterizing pharmaceutical tablet coatings in the thickness range of 10-140 mu m. We found that the spectral OCT system developed in-house has an axial resolution of 0.9 mu m, and is capable of quantifying very thin coatings in the range of 10-60 mu m. The upper limit of 60 mu m within the tablet coating and core is owed to the strong scattering of OCT light, which has relatively short wavelengths in the range of 0.5-1.0 mu m. On the other hand, TPI utilizes terahertz radiation that has substantially long wavelengths in the range of hundreds of microns, and thus is less prone to the scattering problem. Consequently TPI has been demonstrated to be able to quantify thicker coatings in the range of 40-140 mu m and beyond. We concluded that OCT and TPI are two complementary analytical techniques for non-destructive and quantitative characterization of pharmaceutical tablet coatings. (C) 2010 Elsevier Ltd. All rights reserved.
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