Journal
OPTICS AND LASERS IN ENGINEERING
Volume 46, Issue 12, Pages 911-914Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.optlaseng.2008.05.004
Keywords
Glucose; Sclera; Permeability; Concentration; Optical coherence tomography
Categories
Funding
- W. Coulter Foundation
- Office of Naval Research
- Federal Agency of Education of RF [1.4.06, RNP.2.1.1.4473]
- CRDF BRHE [RUXO-006-SR-06]
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In this study, optical coherence tomography (OCT) was utilized in the functional imaging of glucose diffusion through scleral tissues. Permeability coefficients for different concentrations of glucose were quantified nondestructively. Obtained results indicate an inverse proportionality between the permeability coefficient and the concentration of the analyte in epithelial tissues: in-depth diffusion of solutions with lower glucose concentration was faster than those with a higher concentration. The permeability coefficient decreased from (1.67 +/- 0.17) x 10(-5)cm/s of 10% glucose solution to (5.08 +/- 0.23) x 10(-6)cm/s of 25% glucose solution. The dependence of the permeability on the concentration of hyperosmotic analytes could potentially be used in various basic science and clinical fields, such as optical clearing of tissues and cells as well as in clinical pharmacology. Published by Elsevier Ltd.
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