Journal
OPTICAL MATERIALS
Volume 35, Issue 10, Pages 1852-1858Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.optmat.2013.03.028
Keywords
Nanoparticles; Persistent luminescence; Optical imaging; Surface functionalization; In vivo imaging; Biodistribution
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Funding
- French region Ile de France [I07-876/R]
- French National Agency (ANR) in the frame of its program in Nanosciences and Nanotechnologies (NATLURIM Project) [ANR-08-NANO-025]
- European community (EC-DG research) through the FP6-Network of Excellence (CLINIGENE) [LSHB-CT-2006-018933]
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We have recently introduced the use of persistent luminescence nanoparticles, or long-lasting phosphors, for in vivo bioimaging applications in living animals. Red long-lasting phosphors possess an emission located in the tissue transparency window, between 600 and 900 nm, allowing their use for in vivo imaging. Thanks to their optical properties, such nanoparticles can be excited before their systemic injection, allowing highly sensitive detection without any autofluorescence. This article reviews our recent work describing the influence of crystal size and surface state on the biodistribution of persistent luminescence nanoparticles after intravenous injection in living animal. Moreover, additional results from this collaboration show that a proper understanding of the fundamental mechanism associated with persistent luminescence in these silicate-based structures constitutes a major help to improve the optical properties of PLNP, resulting in a longer observation of the nanoprobes in vivo. Such promising results offer interesting perspectives for the development of persistent luminescence nanophosphors intended for long-term applications in living animals. (c) 2013 Elsevier B.V. All rights reserved.
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