Journal
TETRAHEDRON-ASYMMETRY
Volume 26, Issue 17, Pages 912-917Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetasy.2015.07.006
Keywords
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Funding
- National Research Foundation of Korea (NRF) - MEST [2012-006431]
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Chromanone-2-carboxylates and chroman-2-carboxylates are useful building blocks for the synthesis of a variety of bioactive compounds, such as repinotan, fidarestat, and nebivolol. An efficient and practical enantiospecific synthesis of chromanone-2-carboxylates and chroman-2-carboxylates has been accomplished using intramolecular Mitsunobu etherification of methyl (S)-2-hydroxy-4-oxo-4-(2'-hydroxy)phenylbutanoates derived from L-malic acid. (C) 2015 Elsevier Ltd. All rights reserved.
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