4.4 Article

Alkaline earth metal catalyzed cascade, one-pot, solvent-free, and scalable synthesis of pyranocoumarins and benzo[b]pyrans

Journal

TETRAHEDRON LETTERS
Volume 56, Issue 13, Pages 1649-1653

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2015.02.023

Keywords

Pyranocoumarins; Benzopyrans; Ca(II) catalysis; Solvent-free synthesis; Cascade synthesis

Funding

  1. UGC
  2. Central University of Rajasthan
  3. DST - India

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Ca(OTf)(2) catalyzed, cascade, one-pot, conjugate addition and annulation of various nucleophiles to the alpha,beta-unsaturated carbonyl compounds for the synthesis of biologically potent pyranocoumarins and benzo[b]pyrans has been illustrated. This one-pot, solvent-free, green-synthesis employs simple reaction conditions, with high yields and endures the substrate diversity. (C) 2015 Elsevier Ltd. All rights reserved.

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