Novel rearranged and highly oxygenated abietane diterpenoids from the leaves of Tripterygium wilfordii

Two novel rearranged abietane diterpenes, triptergulide A (1) containing a fused 5/6/6/3/6/4 hexacyclic system and triptergulide B (2), possessing both 7/12 and 13/14 oxygen bridges, and two new 18(4 -> 3)-abeo-abietanes, triptergulides C and D (3-4), together with three known diterpenoids (5-7) were isolated from the leaves of Tripterygium wilfordii. Among these compounds, compounds 5-7 exhibited inhibitory effects on HIV-1 replication with an IC50 range of 0.027-0.98 mu M. Compounds 1, 2, 5, and 6 demonstrated inhibitory effects that were similar to the inhibitory effects of dexamethasone on nitric oxide production in LPS-induced macrophages at a concentration of 10 mu M in an in vitro bioassay. (C) 2015 Elsevier Ltd. All rights reserved.