Journal
TETRAHEDRON LETTERS
Volume 56, Issue 31, Pages 4616-4618Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2015.06.035
Keywords
Fused piperazine-benzimidazole; Microwave irradiation; UDC strategy; Nucleophilic substitution reaction; One-pot procedure
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Funding
- Scientific Research Foundation of Chongqing University of Arts and Sciences [R2013XY01, R2013XY02]
- Chongqing Science and Technology Commission [CSTC2013JCYJA50028]
- SRF for ROCS
- SEM
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Two series of compounds containing fused piperazine-benzimidazole scaffolds have been synthesized using an Ugi/deprotection/cyclization strategy (UDC) followed by an intermolecular nucleophilic substitution reaction. This new strategy allows for the facile synthesis of compounds in a one-pot reaction giving fused piperazine-benzimidazoles in good yields. This synthetic strategy can be readily applied to the construction of a diverse range of compounds for high throughput screening in medicinal chemistry. (C) 2015 Elsevier Ltd. All rights reserved.
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