Journal
TETRAHEDRON LETTERS
Volume 56, Issue 23, Pages 3486-3488Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2015.02.121
Keywords
Nickel; Cross-coupling; Stereospecific; Anti-cancer agent; Triarylmethane
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Funding
- NIGMS NIH HHS [R01 GM100212] Funding Source: Medline
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A stereoselective synthesis of a bioactive triarylmethane is described. Key to the synthesis is a nickel-catalyzed Suzuki-Miyaura coupling which proceeds with retention at the benzylic center. This method is complementary to our previously reported nickel-catalyzed Kumada coupling which proceeds with inversion. Together, the two methods allow for efficient access to either enantiomer of biologically relevant triarylmethanes from a common enantioenriched intermediate. (C) 2015 Elsevier Ltd. All rights reserved.
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