4.4 Article

Selective pyrone functionalization: reductive alkylation of triacetic acid lactone

Journal

TETRAHEDRON LETTERS
Volume 56, Issue 23, Pages 3494-3496

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2015.01.141

Keywords

2-Pyrone; Triacetic acid lactone; Reductive alkylation; Aldehydes; Hantzsch ester

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The one-pot reaction of aldehydes, triacetic acid lactone, and Hantzsch 1,4-dihydropyridine affords 3-alkyl pyrones via a reductive alkylation strategy. (C) 2015 Elsevier Ltd. All rights reserved.

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