4.4 Article

An improved aldol protocol for the preparation of 6-styrenylpyrones

Journal

TETRAHEDRON LETTERS
Volume 56, Issue 51, Pages 7112-7114

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2015.11.021

Keywords

2-Pyrone; Triacetic acid lactone; Aldol reaction; Aldehydes; Styrenylpyrones

Funding

  1. NSF [EEC-0813570]

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An improved aldol protocol for the synthesis of 6-styrenylpyrones is reported. The first synthesis of PTP1B inhibitor 1 and 4 has been described. (C) 2015 Elsevier Ltd. All rights reserved.

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