Journal
TETRAHEDRON LETTERS
Volume 56, Issue 44, Pages 5999-6002Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2015.09.042
Keywords
Pyrimidines; Pyrido[2,3-d]pyrimidines; 3-Cyano-2-aminopyridines; Solvent-free; Formamidine
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Funding
- Ministere de la Recherche et des Nouvelles Technologies
- Region Basse-Normandie
- European Union (FEDER funding)
- French Agence Nationale de la Recherche (ANR) [ANR-10-LABX-09-01]
- DGRST
- University of Tlemcen
- CNRS (Centre National de la Recherche Scientifique)
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We describe in this Letter, a novel series of pyrido[2,3-d]pyrimidines 6-11 derived from 3-cyano-2-aminopyridines 4a-f via formamidine formation 5a-f followed by selective nucleophilic addition, with different primary amines, under solvent-free conditions. The structures of the newly synthesized compounds are confirmed by spectral analysis. This new approach includes some important aspects such as mild reaction conditions, high yields, and environmentally friendly process. The operational simplicity of this synthetic route will offer an attractive alternative to the conventional methods. (C) 2015 Elsevier Ltd. All rights reserved.
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