4.4 Article

Two new isopimarane diterpenoids from the endophytic fungus Xylaria sp SNB-GTC2501

Journal

TETRAHEDRON LETTERS
Volume 56, Issue 31, Pages 4596-4598

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2015.06.022

Keywords

Xylaria sp.; Endophytic fungus; Isopimarane

Funding

  1. Agence Nationale de la Recherche (CEBA) [ANR-10-LABX-0025]

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Two new isopimarane diterpenoids, xylabisboein A (1) and B (2), as well as three known secondary metabolites (i.e., (-)-5-methylmellein (3), mellein-5-carboxylic acid (4) and ergosterol peroxide (5)), were isolated from a solid culture of the endophytic fungus Xylaria sp. SNB-GTC2501. The structures were elucidated by spectroscopic analysis and the absolute configuration of xylabisboein A (1) was determined by X-ray crystallographic analysis. All of the compounds were tested for their antimicrobial and cytotoxic activities. (C) 2015 Published by Elsevier Ltd.

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