Journal
OPHTHALMOLOGICA
Volume 226, Issue 3, Pages -Publisher
KARGER
DOI: 10.1159/000328981
Keywords
Age-related macular degeneration; Age-related maculopathy; Genetic factors; Personalized medicine; Missing heritability; Genome-wide association studies; Atrophic age-related macular degeneration; Exudative age-related macular degeneration; Complement factor H gene (CFH); LOC387715; Age-related maculopathy susceptibility 2 gene (ARMS2); HtrA serine peptidase 1 gene (HTRA1); Complement component 2, 3, 9 (C2, C3, C9); Genetic profiling; Asian
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Age-related macular degeneration (AMD) is a complex, multifactorial disease associated with environmental and genetic factors. This review emphasizes the clinical impact of the major genetic factors mainly located in the complement factor H gene and on the 10q26 locus, and their current and future implications for the management of AMD. Copyright (C) 2011 S. Karger AG, Basel
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