Journal
TETRAHEDRON LETTERS
Volume 56, Issue 17, Pages 2193-2196Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2015.03.034
Keywords
Aromatic chlorination; Catalytic thiourea; Halogen bond; N-Chlorosuccinimide
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Funding
- Mahidol University International College
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A metal and acid-free electrophilic aromatic chlorination methodology involving catalytic thiourea activation of N-chlorosuccinimide (NCS) is reported herein. Moderate yields and regioselectivities of chlorinated aromatics were obtained using a combination of 1.05-1.15 equiv of NCS and 5 mol % of thiourea at room temperature in acetonitrile. A halogen bond between the sulfur atom of thiourea and the sigma-hole of the NCS chlorine atom is thought to enhance the electrophilic activity of the chlorine of NCS. (C) 2015 Elsevier Ltd. All rights reserved.
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